Sunday, February 9, 2025

Statistical Sampling of the Olfactory Environment


It appears that a discovery has been made, all over the place and all at once, about how the mixture of air changes the way smells are perceived. 

It's not at all unusual that multiple simultaneous discoveries have appeared, in fact it's the rule not the exception in science. The articles below all seem to have discovered that a turbulent cloud of odor molecules smells different than what I'll call a more homogenous, slow-moving cloud. 

Based on the above image, see the great CFD video illustration of air movement here.

It's like you're getting a more representative sample. When smells occur in your environment, they move as streams and plumes, picture wisps of smoke. If you're about to "sample" a piece of data, it means you're about inhale a cubic foot of air. What are the chances the amount of molecules you need to register an odor will be in that cubic foot? If you were to snapshot the cube before you inhale, you could imagine the airsteams of the odor you're looking for, let's say the scent of a female moth pheromone, twirling through the cube. But if you shook up all the air around you, to get into your breathing space some of the airstreams from outside the space, then you get more chance that the target molecule will make it into your "sample" sniff. From a statistical point of view it does make sense - you're squeezing more airstreams into a smaller space and time.

Study suggests that 'Jedi' rodents remotely move matter using sound to enhance their sense of smell
Oct 2024, phys.org

Surprise! "This phenomenon has never been observed before, or I believe even suspected, in any animal"

(This is from a bioacoustics researcher btw.)

Scientists have debated the purpose of the ultrasonic vocalizations (USVs) produced by rodents since the discovery of these sounds in the 1950s. This new paper suggests they do it to shake up their surroundings in ways that influence how inhaled particles enter their noses, suggesting that rodents use sound to enhance their sense of smell.

"They're creating new pathways of information by manipulating their environment and controlling the molecular interactions of particles around them."

Rodents explore their environment by stroking surfaces with their whiskers, visually scanning, and incessantly sniffing. Mercado discovered that studies on vocalizations that also monitored sniffing showed that rodents immediately sniffed after producing each USV.

"That could be a coincidence, or it might suggest the two are functionally related," he says. "I knew that techniques for using ultrasound to manipulate particles are used in the field of vibroacoustics and thought immediately that might also work for animals."

Vibroacoustics, or artificially produced ultrasonic vibrations, cause airborne particles to cluster, leading Mercado to suggest that rodents are using USVs to create odor clusters enhancing the reception of pheromones (chemical signals), thus making it easier for the vocalizer to detect and identify friends, strangers, and competitors.

via University at Buffalo: Eduardo Mercado et al, Do rodents smell with sound?, Neuroscience & Biobehavioral Reviews (2024). DOI: 10.1016/j.neubiorev.2024.105908. 


Study uncovers how silkworm moth's odor detection may improve robotics
Oct 2024, phys.org

They employed high-speed photogrammetry to computationally analyze the aerodynamic consequences of wing motions of the silkworm moth (Bombyx mori).

This insect that no longer flies due to domestication, but does flap its wings when they detect pheromones.

One of the key findings of the study was that B. mori samples the pheromone selectively from the front. The moth scans the space by rotating its body while fanning to locate the pheromone sources. The directional sampling of the pheromone molecules is particularly helpful when searching for an odor source since the moth can determine the direction of the odor plume upon the detection of the pheromone.

This could lead to advancements in robotic odor source localization technologies, where drones equipped with insect antennae for odor detection carefully adjust their orientation and the configuration of their propellers and odor sensors to optimize detection capabilities.

via Chiba University Graduate School of Engineering: Olfactory sampling volume for pheromone capture by wing fanning of silkworm moth: a simulation-based study, Scientific Reports (2024). DOI: 10.1038/s41598-024-67966-y


People with no sense of smell found to have abnormal breathing patterns
Oct 2024, phys.org

The researchers sought to address anecdotal accounts of people who could not smell and began "breathing funny" after contracting COVID-19.

The research team recruited 52 volunteers, 21 of whom were suffering from anosmia, and fitted them with a breathing monitor for 24 hours.

The research team found that those volunteers with anosmia did have slightly different than normal breathing patterns. People without the condition, they note, have small inhalation peaks, which prior research suggests coincides with a suspected change in smell. People without the ability to smell had no such peaks.

via The Azrieli National Institute for Human Brain Imaging and Research: Lior Gorodisky et al, Humans without a sense of smell breathe differently, Nature Communications (2024). DOI: 10.1038/s41467-024-52650-6

Saturday, February 8, 2025

Personal Olfactory Identification Information

 

Two things we will never fully understand, the human body, and olfaction, together.

Researchers explain the dissimilar smells of babies and teenagers
Mar 2024, phys.org

The researchers recruited the parents of 18 children aged up to 3 years old to wash the youngsters with a fragrance-free gel and to take swap samples of the armpits of their pajamas prior to sleep. They did the same with 18 teenagers between the ages of 14 and 18. All the cotton pads were then collected and analyzed in a lab setting.

The research team used mass spectrometry to identify the chemical compounds in the pads, and used gas chromatography along with a human sniffer to assess the odorousness of the smells associated with each chemical compound.

The researchers found that most of the chemicals responsible for body odor were similar between the two groups of volunteers. But there were a few that made the difference. Teenage sweat, for example, had high levels of many kinds of carboxylic acids, which the assessors described as "earthy, musty or cheesy."

They also found two steroids in the teen sweat not present in the baby sweat, one of which resulted in "musk or urine-like" emanations - the other, the assessors suggested, smelled more like "musk and sandalwood." Without such chemicals, the sweat of babies smelled much sweeter.

via a team of aroma chemists at Friedrich-Alexander-Universität Erlangen-Nürnberg with psychologists from Technical University of Dresden: Diana Owsienko et al, Body odor samples from infants and post-pubertal children differ in their volatile profiles, Communications Chemistry (2024). DOI: 10.1038/s42004-024-01131-4



Clothes are like your second skin, so we can also call this body odor:

Textile scientists offer fresh insights on why some clothes get smellier
Jul 2024, phys.org

Cotton and viscose, which are cellulosic, or plant-derived fibers, absorbed - and consequently released - smaller amounts of odor-causing compounds than polyester, nylon and wool.

"Although we know that polyester is smellier after being worn next to sweaty armpits compared to cotton T-shirts, we haven't really known why."

"If you had a sweaty armpit that never actually touched the shirt you're wearing, then the fabric wouldn't get very smelly." The researchers soaked the fibers in the sweat solution for different periods of time, then examined the release of various odor-causing compounds.

Sweat is mostly made up of water but also has oily compounds that bacteria transform to form odors, and these oily compounds in watery sweat can interact differently with textiles, depending on the fiber chemistry.

"While water-loving cellulosic fibers such as cotton and viscose absorb more of the water from sweat than polyester does, polyester doesn't want to absorb the water. It's more oil-loving, and it absorbs more of the odorants, which don't dissolve in water, and more of the oily compounds.

The research also showed that although nylon and wool initially took in a lot of the odorants from the sweat, they dissipated them more quickly than polyester. After 24 hours, wool and nylon had much lower intensities of the odorants and were more similar to the cellulosic fibers.

"That tells us that while polyester still needs to be washed, for nylon and wool garments, people might be able to freshen them by just airing them out rather than laundering every time."

Bonus:
"The study's method of using simulated liquid sweat also offers an important fresh approach to exploring the issue."

via New University of Alberta and University of Otago in New Zealand: Rachel H McQueen et al, Textile sorption and release of odorous volatile organic compounds from a synthetic sweat solution, Textile Research Journal (2024). DOI: 10.1177/00405175241249462


Does fertility affect a woman's body odor? Study finds no evidence
Jul 2024, phys.org

The researchers took samples of underarm odor from 29 women on 10 days spread over a menstrual cycle. A group of 91 men were then asked to rate the odor samples. In 16 of the women, the research team also looked at whether the chemical composition of the odor samples differed between the women's fertile and infertile days.

The results of both tests pointed in the same direction: there was no evidence from the odor ratings that men found a woman's odor more attractive on her fertile days than on her infertile days. 

Chemical analysis of the odor samples also showed no correlation between the composition of the underarm odor and the women's current fertility status.

via Leipzig University, the Max Planck Institute for Evolutionary Anthropology and the University of Göttingen: Madita Zetzsche et al, Combined perceptual and chemical analyses show no compelling evidence for ovulatory cycle shifts in women's axillary odour, Proceedings of the Royal Society B: Biological Sciences (2024). DOI: 10.1098/rspb.2023.2712


Friday, February 7, 2025

Olfactory Therapy Sounds Like Aromatherapy



Not sure I can believe all this - because you know as they say, extraordinary claims require extraordinary evidence. 

We're talking about a thing called therapeutic olfactory stimulation, also called olfactory enrichment and olfactory therapy. We start with the first study, which says: 

"Olfactory enrichment can improve the memory of older adults by 226%" 

They took 43 people over 60 years old and exposed them to 7 different odorants a week, one per night, for 2 hours, using an odorant diffuser, and then gave them the Rey Auditory Verbal Learning Test where they saw improved scores, and gave them fMRI scans that showed improved functioning in the left uncinate fasciculus as assessed by mean diffusivity.

I'm not a research scientist working in a lab and writing papers, and so the only thing I see here that's a flag is that the study took place during the covid lockdown, and something about social interaction related to the study could definitely improve brain health, because we know that happens. But that also caused lots of other problems like how they had to remove people from the study because their baseline taken in the office might be so different from follow-ups done remotely. 

They do reference a few other studies that support this idea, so I'll just copy directly:  
...olfactory stimulation during sleep deepens slow-wave sleep (Wolfe and Herzberg, 1996; Goel et al., 2005), which is the most restful portion of the sleep cycle, and people report feeling more vigorous the next day after nighttime olfactory exposure (Goel et al., 2005). Odorants enhance normal sleep, and they also improve abnormal sleep at a magnitude similar to that of sleep medication (Hardy and Kirk-Smith, 1995).

Bottom line is, I think we are eagerly awaiting another study, done not-during a pandemic and with a larger group beyond the 43 people participating here. 

via University of California Irvine Center for the Neurobiology of Learning and Memory: Overnight olfactory enrichment using an odorant diffuser improves memory and modifies the uncinate fasciculus in older adults. Cynthia C. Woo, Blake Miranda, Mithra Sathishkumar, Farideh Dehkordi-Vakil, Michael A. Yassa, Michael Leon. Frontiers in Neuroscience, 2023; 17 DOI: 10.3389/fnins.2023.1200448 [full text available]



But not so fast, we're not done yet. If the results from the above study are found to be credible, that would make the study below a lot more important:

Smell loss is linked to more than 100 diseases in new study
Oct 2024, phys.org

"We now know that pleasant scents can decrease inflammation, potentially pointing to the mechanism by which such scents can improve brain health." The study delves into the methodical tracking of 139 medical conditions associated with both olfactory loss and heightened inflammation, uncovering insights into a shared pathway linking these factors. Olfactory loss, which often precedes conditions such as Alzheimer's and Parkinson's diseases, may serve as an early indicator of disease onset, allowing for more proactive therapeutic approaches.

By showing how olfactory enrichment can mitigate inflammation, this research has laid a foundation for future studies aiming to explore the therapeutic use of scent to address a broader range of medical conditions.

via Charlie Dunlop School of Biological Sciences at University of California Irvine and Oxford Research Centre in the Humanities: Michael Leon et al, Inflammation and olfactory loss are associated with at least 139 medical conditions, Frontiers in Molecular Neuroscience (2024). DOI: 10.3389/fnmol.2024.1455418

Thursday, February 6, 2025

Male vs Female

 

Insects are not like people, because they have antennae instead of noses, and because they use pheromones and we don't. Still, it's always good to remember that when it comes to the chemosensory world, there's always a difference between males and females:

The differing olfactory worlds of female and male silk moths
Jan 2024, phys.org

Male moths live in a completely different olfactory world to their female counterparts. For example, the antennae of male silk moths are highly specialized to detect female sex pheromones like bombykol and bombykal, while females cannot even smell their own pheromones.

Bombykol attracts and bombykal deters, for males.

For females, they can't smell any of that. Instead they smell isovaleric acid and benzaldehyde, which are in silkworm feces, which can be found on mulberry trees, since they are the only trees where silk worms live, and they're also where silk moths want to lay eggs.

via Max Planck Institute for Chemical Ecology and Martin Luther University Halle-Wittenberg: Females smell differently: characteristics and significance of the most common olfactory sensilla of female silkmoths, Proceedings of the Royal Society B: Biological Sciences (2024). DOI: 10.1098/rspb.2023.2578



Study suggests an 'odor sensor' may explain male and female differences in blood pressure
Mar 2024, phys.org

Blood pressure in premenopausal human and mouse females is typically 10 points lower in both diastolic and systolic pressure than in males. Some studies suggest the difference may be caused by sex hormones, but the biological basis for the variation is not entirely clear.

Olfactory receptors are found all over the body, in lots of places that are not only in our nose, like in our kidneys for example (and on the surface of our skin but I don't have the science for that, only personal experience). Anyway, they've now found an olfactory receptor lining blood vessel walls of a part of the kidney that releases a blood pressure hormone called renin. 

Olfacotry receptors each have their own gene, so it's easy to look at a population and select people with mutations of this gene, which they did. These people, women, who didn't have the gene also had blood pressure levels just like men. 

via Johns Hopkins University School of Medicine and Queen Mary University of London: Jiaojiao Xu et al, An Evolutionarily Conserved Olfactory Receptor is Required for Sex Differences in Blood Pressure, Science Advances (2024). DOI: 10.1126/sciadv.adk1487.

Wednesday, February 5, 2025

Olfactory Otherness


I have a crazy idea there's a correlation between the rise of anxiety in a population and the decline in body odor due to deodorant and hygiene practices, as well as due to the increased availability of privacy, which is what I'll call the ability for each of us to have our own bedroom when growing up, or to live in an apartment alone as an adult, things that weren't available back in time because of financial constraints. That being said, the studies below do seem to suggest that smell has a stronger effect on our emotional states and our mental health status then we are aware of. 


Research shows that sniffing women's tears reduces aggressive behavior in men
Dec 2023, phys.org

Science strikes again!
  • They use the words "emotional tears" just to clarify. (not all tears are created equal)
  • The men played a two-player game where they were allowed to get revenge on the opponent.
  • Revenge-seeking aggressive behavior during the game dropped more than 40% after the men sniffed women's emotional tears.

via Weizmann Institute of Science: Agron S, de March CA, Weissgross R, Mishor E, Gorodisky L, Weiss T, et al. (2023) A chemical signal in human female tears lowers aggression in males. PLoS Biology (2023). DOI: 10.1371/journal.pbio.3002442



Scents might help depressed individuals, new study says
Feb 2024, phys.org

Scents are more effective than words at bringing back a memory of a specific event and could even be used in the clinical setting to help depressed individuals get out of the negative thought cycles and rewire thought patterns, aiding faster and smoother healing.

"It was surprising to me that nobody thought to look at memory recall in depressed individuals using odor cues before"

Professor Young presented study participants with a series of opaque glass vials containing potent familiar scents—from oranges and ground coffee to shoe polish, and even Vicks VapoRub. After asking participants to smell the vial, Young asked them to recall a specific memory, whether good or bad.

via University of Pittsburgh: Kymberly Young et al, Recall of Autobiographical Memories Following Odor vs Verbal Cues Among Adults With Major Depressive Disorder, JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2023.55958

 
Study finds social interactions and olfactory cues prompt contagious itch in mice
Jun 2024, phys.org

Contagious itch only occurs in mice when they observe if a mouse that has been in their proximity is scratching.

Anosmic observer mice, whether itch-naïve or itch-experienced, displayed no contagious itch behavior.

via Tehran University of Medical Sciences: Shayan, M. et al. Social interactions and olfactory cues are required for contagious itch in mice. Scientific Reports(2024). DOI: 10.1038/s41598-024-61078-3.


Research shows young infants use their mother's scent to perceive faces
Jul 2024, phys.org

We tested 50 infants aged from 4 to 12 months, and found that the face-selective EEG response increases and complexified, indicative of improved face perception with development.

As expected, we also found that the benefit of adding the mother's body odor diminishes with age, confirming an inverse relation between the effectiveness of visual perception and its sensitivity to a concurrent odor.

Overall, this demonstrates that visual perception actively relies on odor cues in developing infants until the visual system becomes effective by itself.

What surprised me the most, not only in these studies but also in the previous studies we conducted, is the fact that the mother's odor has such a strong effect on the perception of various unfamiliar faces ... by showing reduced reactions to fearful faces, higher attention toward an unfamiliar woman, and increased interbrain synchrony between the infant and that woman.

Thus, it seems like the mother's body odor reassures the infant and promotes their interest when they encounter novel people. In other words, this primary social odor that infants learn already in the womb seems to encourage prosocial cognitions and behaviors.

via Society for Research in Child Development, Development of Olfactory Communication & Cognition  Lab in the Center for Taste, Smell and Feeding Sciences at Université de Bourgogne, University of Hamburg, Université de Lyon, Institut Universitaire de France, Université de Lorraine, Centre Hospitalier de Nancy, and Centre National de la Recherche Scientifique CNRS: Olfactory-to-visual facilitation in the infant brain declines gradually from 4 to 12 months, Child Development (2024). DOI: 10.1111/cdev.14124


Smell of human stress can affect dogs' emotions, leading them to make more pessimistic choices
Jul 2024, phys.org

Dogs experience emotional contagion from the smell of human stress.

The researchers recruited 18 dog-owner partnerships to take part in a series of trials with different human smells present. During the trials, dogs were trained that when a food bowl was placed in one location, it contained a treat, but when placed in another location, it was empty. Once a dog learned the difference between these bowl locations, they were faster to approach the location with a treat, which reflected 'optimism', while a slow approach indicated 'pessimism'.

These trials were repeated while each dog was exposed to either no odor or the odors of sweat and breath samples from humans in either a stressed or relaxed state. The stress smell made dogs slower to approach the ambiguous bowl.

via University of Bristol Veterinary School: Parr-Cortes, Zoe ; Muller, Carsten T ; Talas, Laszlo et al, The odour of an unfamiliar stressed or relaxed person affects dogs' responses to a cognitive bias test, Scientific Reports (2024). DOI: 10.1038/s41598-024-66147-1


Emotional body odors may enhance the effect of mindfulness therapy
Nov 2024, phys.org

48 women with symptoms of social anxiety and 30 women with depression were divided into three different groups exposed to either happiness body odor, fear body odor, or clean air, then tasked with performing mindfulness exercises over two consecutive days.

"The results were quite surprising as we observed an enhanced symptom reduction for individuals with social anxiety that received chemosignals, regardless of whether they came from fear or happiness body odors. This may indicate that it is not the emotion itself that leads to the improved effect, but perhaps rather that chemosignals convey a kind of 'human presence.'"

Two nuanced results: 1. Exposure to fear body odor resulted in lower heart rate variability indicating a less relaxed state even though this was not reflected in the self-reported anxiety ratings, and 2. No differences were seen for the group with depressive symptoms, only anxiety.

via Karolinska Institutet and National Center for Suicide Research and Prevention: Cinzia Cecchetto et al, Sniffing out a solution: How emotional body odors can improve mindfulness therapy for social anxiety, Journal of Affective Disorders (2024). DOI: 10.1016/j.jad.2024.10.088

Tuesday, February 4, 2025

Fragrance Generators



Text generators and image generators and even video generators have been hitting the streets and hitting our screens for a while now, but let's not forget the molecule generators, maybe we could call them chemical generators and make it real confusing (they're generating possible chemicals, like the formula for a chemical not yet known by science, not actual chemicals; that's for a different robot). 

Perfume engineering uses trial-and-error to find new fragrant chemicals. That's how we do everything before we know how to do it. It's very inefficient. So now we're trying to use machine learning to take at least some of the guessing out of all this. And it works, sort of. 

Machine learning gives us new molecules to work with, but it doesn't tell us how to combine those molecules with others. It can't predict the perceived intensity of the just-discovered but not-yet-created molecule.

Molecules yes, perception no.

Perfumes have no copyright protections; they are protected by the inability for people to guess the composition. You can get the molecules right, but not the amounts relative to each other; changing the ratio of even two molecules from 10:1 to 10:3 is enough to mess up the overall effect.

So this effort is to predict the overall effect of a bunch of molecules mixed toegther, not just one but a bunch together. They train a neural net using molecules and words. I can't really tell which word-dataset they're using, because it seems to be proprietary, and based on Teixeira et al's 2014 Perfumery Radar 2.0 (https://sci-hub.se/10.1021/ie403968w).


Using AI to replicate odors and validating them via experimental quantification of perfume perception
Mar 2024, phys.org

via Norwegian University of Science and Technology: Bruno C. L. Rodrigues et al, Molecule Generation and Optimization for Efficient Fragrance Creation, arXiv (2024). DOI: 10.48550/arxiv.2402.12134



I'm skeptical because the list is so short, but it might be as simple as this: citrus, fruity, green, floral, herbaceous, musk, oriental, and woody; and based on the rationale that this small group represents 75% of the odor space (Teixeira 2010). 

There are less common descriptors such as leather, gourmand, aldehydic, balsamic, and herbal which are used only twice. One dimensional descriptors are tobacco, modern chypre, floral oriental, soft oriental, mossy woods, dry woods, and mint, among others. Some molecules didn't come with their own notes, so Good Scents was used as a reference.

Here's a list of the lexica for odor descriptions mentioned in the Perfumery Radar text - Calkin and Jellinek, Jaubert, Roudnitska, Edwards' Fragrance Wheel, Zarzo and Stanton, Boelens-Haring and Thiboud. Apart from these, each fragrance company or perfumer has their own that they've developed over the years. The Perfumery Radar 2.0 itself uses a base layer with eight olfactory families, and two additional layers: an outer layer with seven descriptors and an inner layer with 17 descriptors. 

And here's the info from their table on the most used descriptors by fragrance companies: floral, woody, citrus, fruity, green, oriental, chypre, aromatic, fouger̀e, musk, spicy, ambery, marine; used in different ways by Givaudan, Osmoz, International Flavors & Fragrances, Symrise, Frutarom, MANE, Societ́é Franca̧ise des Parfumeurs (SFP), The Fragrance Foundation, Avon, Fragrantica, LaLoff.

They talk about the difference between using common words for olfactory perception and the more limited set of words used by expert perfumers, which is an important part of constructing these lexica, and also that each fragrance house maps the olfactory space in its own way. 

via Chemical Engineering Department of the Norwegian University of Science and
Technology, Laboratories of Separation and Reaction Engineering and of Catalysis
and Materials and of Chemical Engineering at University of Porto, and SIA Murins Startups in Latvia:  BC Rodriguex et al. Molecule Generation and Optimization for Efficient Fragrance Creation.  

Monday, February 3, 2025

Brother of E-Nose

 

This is about not your Grandma's electronic nose, but other versions that have been showing up:

Researchers develop biomimetic olfactory chips to enable advanced gas sensing and odor detection
Mar 2024, phys.org

Most electronic noses work electrochemically, but this one is biomimetic, so that's new.

"In the future, with the development of suitable bio-compatible materials, we hope that the biomimetic olfactory chip can also be placed on the human body to allow us to smell an odor that normally cannot be smelled. It can also monitor the abnormalities in volatile organic molecules in our breath and emitted by our skin, to warn us on potential diseases, reaching further potential of biomimetic engineering," said Prof. Fan.

via Hong Kong University of Science and Technology: Chen Wang et al, Biomimetic olfactory chips based on large-scale monolithically integrated nanotube sensor arrays, Nature Electronics (2024). DOI: 10.1038/s41928-023-01107-7



Combining human olfactory receptors with artificial organic synapses and a neural network to sniff out cancer
May 2024, phys.org

The device has three parts. a nanodisk containing modified human olfactory receptors grown using E. coli bacteria, a device that simulates neural synapses, and an artificial neural network trained on four specific fatty acids that are known to be present in breath samples of people with certain types of gastric cancers.

The research team plans to continue their work by adding more receptors.

(Only 400 receptors to go!)

via Seoul National University: Hyun Woo Song et al, A pattern recognition artificial olfactory system based on human olfactory receptors and organic synaptic devices, Science Advances (2024). DOI: 10.1126/sciadv.adl2882


Artificial 'nose' can sniff out damaged fruit and spoiled meat
Oct 2024, phys.org

Ah yes - The Antenna Nose:

"Other electronic noses can have several hundred sensors, often each coated with different materials. This makes them both very power-intensive to operate and expensive to manufacture. They also entail high material consumption. In contrast, the antenna sensor consists of only one antenna with one type of coating."

The antenna transmits radio signals at a range of different frequencies into the surroundings. It then analyzes how they are reflected back. The way the signals behave changes based on the gases present, and because the antenna transmits signals at multiple frequencies, the changes create unique patterns that can be linked to specific volatile organic compounds - even isomer compounds that "look" very similar to even the most sophisticated E-noses.

via Department of Manufacturing and Civil Engineering at Norwegian University of Science and Technology: Yu Dang et al, Facile E-nose based on single antenna and graphene oxide for sensing volatile organic compound gases with ultrahigh selectivity and accuracy, Sensors and Actuators B: Chemical (2024). DOI: 10.1016/j.snb.2024.136409


Tiny electronic nose rivals animal scent detection
Nov 2024, phys.org

They measure the timing and frequency of odor bursts in highly chaotic air movements of odor plumes to guess the size and spread of the odor plume.

We found it could accurately identify odors in bursts as short as 50 milliseconds. Even more, it could decode patterns between odors switching up to 40 times per second, which is similar to what mice can do when they perform source-separation tasks. This means our device can "smell" at speeds that match those of animals.

They used metal-oxide gas sensors as well as temperature and humidity sensors, improved with high-end electronics and custom-designed algorithms that can sample and control these sensors fast and precisely. 

"We also discovered that rapidly switching the temperature of the sensors back and forth between 150°C and 400°C about 20 times per second produced quick, distinctive data patterns that made it easier to identify specific smells. This approach allowed our device to pick up odors with remarkable speed and accuracy."

via Biocomputation Group, University of Hertfordshire and International Centre for Neuromorphic Systems at Western Sydney University: Nik Dennler et al, High-speed odor sensing using miniaturized electronic nose, Science Advances (2024). DOI: 10.1126/sciadv.adp1764


Nanopore-based 'artificial tongue' can determine chemical makeup of alcoholic drinks
Dec 2024, phys.org

"A single-molecule sensor for rapid analysis of alcoholic beverages" uses a mycobacterium modified with a pore just a few nanometers in diameter.

via Nanjing University: Pingping Fan et al, Nanopore signatures of major alcoholic beverages, Matter (2024). DOI: 10.1016/j.matt.2024.11.025